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KMID : 1143420170100010010
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Public Health Weekly Report
2017 Volume.10 No. 1 p.10 ~ p.15
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Data release of diabetes-related 11 Korean reference epigenome map
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Bae Jae-Beom
Yoo Jae-Il
Kim Bong-Jo
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Abstract
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BACKGROUND:KNIH recently released 11 sets of diabetes-related epigenome data in cooperation with the International Human Epigenome Consortium. Epigenetics is the study of gene regulation which is affected by several regulatory factors other than genomic sequence. Epigenetic modifications differ from cell, disease type and even in monozygotic twins.
CURRENT STATUS:This study was a collaboration with International Human Epigenome Consortium (IHEC) for the purpose of ensuring human health and preventing diseases. Nine member institutions in eight countries participated in this study. This study is the most comprehensive international collaboration since the Human Genome Project. With domestic collaborations, chronic disease experts from clinical institutions took part in this project. Furthermore, this study was conducted under the umbrella of the IHEC that collected and disseminated 316 reference epigenome data sets. Although previous studies only revealed partial epigenome information on several non-reference epigenome, this study collected comprehensive epigenome data sets from 316 cell types each containing methylome, transcriptome and open chromatin information.
PROSPECTIVE FUTURE:The currently released diabetes-related 11 data sets will pave the road in deciphering the causative role in the pathopysiology of Diabetes.
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